Balipodect
Balipodect (TAK-063) is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.
Product Specifications
CAS Number
1238697-26-1
Product Name Alternative
TAK-063
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/TAK-063.html
Purity
99.47
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
FC1=CC(N2N=CC=C2)=CC=C1N3N=C(C4=CC=NN4C5=CC=CC=C5)C(C(OC)=C3)=O
Molecular Formula
C23H17FN6O2
Molecular Weight
428.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Kunitomo J, et al. Discovery of 1-[2-Fluoro-4- (1H-pyrazol-1-yl) phenyl]-5-methoxy-3- (1-phenyl-1H-pyrazol-5-yl) pyridazin-4 (1H) -one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor. J Med Chem. 2014 Nov 26;57 (22) :9627-43.|[2]Suzuki K, et al. In Vivo Pharmacological Characterization of TAK-063, a Potent and Selective Phosphodiesterase 10A Inhibitor with Antipsychotic-Like Activity in Rodents. J Pharmacol Exp Ther. 2014 Dec 18. pii: jpet.114.218552.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PDE10
Available Sizes
Frequently Asked Questions
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