Balipodect

Balipodect (TAK-063) is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.

Product Specifications

CAS Number

[1238697-26-1]

Product Name Alternative

TAK-063

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/TAK-063.html

Purity

99.47

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

FC1=CC(N2N=CC=C2)=CC=C1N3N=C(C4=CC=NN4C5=CC=CC=C5)C(C(OC)=C3)=O

Molecular Formula

C23H17FN6O2

Molecular Weight

428.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Kunitomo J, et al. Discovery of 1-[2-Fluoro-4- (1H-pyrazol-1-yl) phenyl]-5-methoxy-3- (1-phenyl-1H-pyrazol-5-yl) pyridazin-4 (1H) -one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A) Inhibitor. J Med Chem. 2014 Nov 26;57 (22) :9627-43.|[2]Suzuki K, et al. In Vivo Pharmacological Characterization of TAK-063, a Potent and Selective Phosphodiesterase 10A Inhibitor with Antipsychotic-Like Activity in Rodents. J Pharmacol Exp Ther. 2014 Dec 18. pii: jpet.114.218552.