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Anti-HNRNPU Antibody (C-term)

Boster Bio Anti-HNRNPU Antibody (C-term) (Catalog # M03691-1) . Tested in WB application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA. Plays a role in the circadian regulation of the core clock component ARNTL/BMAL1 transcription (By similarity) .

Synonyms

Heterogeneous nuclear ribonucleoprotein U, hnRNP U, Scaffold attachment factor A, SAF-A, p120, pp120, HNRNPU, HNRPU, SAFA, U211

Gene Name

HNRNPU

UniProt

Q00839

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This HNRNPU antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 766-800 amino acids from the C-terminal region of human HNRNPU.

Clonality

Polyclonal

Tissue Specificity

Widely expressed.

Applications

WB

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Dilution

WB: 1:2000

Function

104906221808260319029303223259912598661028622508132417381745542862250881745549353307104906221571156319617346238113391049062215711563104906221961734693533072381133918082603223259911717430617289661190293031902930317174306212423132598661021242313259866102124231316286258068679817455492048739405365286225087509195132417392048739405365106715441100364511909954286225082624433323811339223259912232599117174306

Molecular Weight

90584 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Fragment

Rabbit IgG

Subcellular Location

Nucleus. Nucleus matrix. Chromosome. Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. Cytoplasm Cell surface. Cytoplasmic granule. Note=Localizes at inactive X chromosome (Xi) regions (PubMed:11003645, PubMed:14608463, PubMed:15563465) Localizes in the nucleus during interphase (PubMed:21242313) . At metaphase, localizes with mitotic spindle microtubules (MTs) (PubMed:21242313) . At anaphase, localizes in the mitotic spindle midzone (PubMed:21242313) . Localizes in spindle MTs proximal to spindle poles in a TPX2- and AURKA-dependent manner (PubMed:21242313) . The Ser- 59 phosphorylated form localizes to centrosomes during prophase and metaphase, to mitotic spindles in anaphase and to the midbody during cytokinesis (PubMed:25986610) . Colocalizes with SMARCA4 in the nucleus (By similarity) . Colocalizes with CBX5 in the nucleus (PubMed:19617346) . Colocalizes with NR3C1 in nuclear speckles (PubMed:9353307) . Localized in cytoplasmic ribonucleoprotein (RNP) granules containing untranslated mRNAs (PubMed:17289661) {ECO:0000250|UniProtKB:Q8VEK3, ECO:0000269|PubMed:11003645, ECO:0000269|PubMed:14608463, ECO:0000269|PubMed:15563465, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:21242313, ECO:0000269|PubMed:25986610, ECO:0000269|PubMed:9353307}

Available Sizes

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