Anti- (Mouse) Suz12 Antibody (Center)
Boster Bio Anti- (Mouse) Suz12 Antibody (Center) (Catalog # M00583-2) . Tested in WB, IHC-P application (s) . This antibody reacts with Human, Mouse.
Product Specifications
Background
Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity) . Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8.
Synonyms
Polycomb protein Suz12, Suppressor of zeste 12 protein homolog, Suz12, D11Ertd530e, Kiaa0160
Gene Name
Suz12
UniProt
Q80U70
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This mouse Suz12 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 381-395 amino acids from the Central region of mouse Suz12.
Clonality
Polyclonal
Tissue Specificity
Expressed in embryonic stem cells.
Applications
WB, IHC-P
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity) . Genes repressed by the PRC2/EED- EZH2 complex include HOXA7, HOXB6 and HOXC8.
Molecular Weight
83026 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
Rabbit IgG
Subcellular Location
Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in trophoblast stem cells
Available Sizes
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