Anti-PIK3R3 Antibody (C-term)
Boster Bio Anti-PIK3R3 Antibody (C-term) (Catalog # A06707-1) . Tested in IF, WB, IHC-P application (s) . This antibody reacts with Human.
Product Specifications
Background
PIK3R3 binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. It is a component of a heterodimer of p110 (catalytic) and p55 (regulatory) subunits. The protein is expressed at highest levels in brain and testis. Lower levels are detected in adipose tissue, kidney, heart, lung and skeletal muscle. The protein contains 2 SH2 domains.
Synonyms
Phosphatidylinositol 3-kinase regulatory subunit gamma, PI3-kinase regulatory subunit gamma, PI3K regulatory subunit gamma, PtdIns-3-kinase regulatory subunit gamma, Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma, PI3-kinase subunit p55-gamma, PtdIns-3-kinase regulatory subunit p55-gamma, p55PIK, PIK3R3
Gene Name
PIK3R3
UniProt
Q92569
Host
Rabbit
Reactivity
Human
Immunogen
This PIK3R3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 316-346 amino acids from the C-terminal region of human PIK3R3.
Clonality
Polyclonal
Tissue Specificity
Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle
Applications
IF, WB, IHC-P
Field of Research
Cancer, Immunology, Signal Transduction, TLR Signaling, T Cells, Chemokine signaling, Apoptosis
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Molecular Weight
54448 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
Rabbit IgG
Available Sizes
Frequently Asked Questions
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