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Anti-JMJD2C Antibody (C-term)

Boster Bio Anti-JMJD2C Antibody (C-term) (Catalog # A04689) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants.

Synonyms

Lysine-specific demethylase 4C, 11411-, Gene amplified in squamous cell carcinoma 1 protein, GASC-1 protein, JmjC domain-containing histone demethylation protein 3C, Jumonji domain-containing protein 2C, KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780

Gene Name

KDM4C

UniProt

Q9H3R0

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

This JMJD2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1023-1056 amino acids from the C-terminal region of human JMJD2C.

Clonality

Polyclonal

Tissue Specificity

Overexpressed in several esophageal squamous cell carcinomas (ESCs) .

Applications

WB, Flow Cytometry

Field of Research

Cancer

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Molecular Weight

119982 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A04689

Product MSDS

https://www.bosterbio.com/msds?sku=A04689

Fragment

Rabbit IgG

Subcellular Location

Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.

Available Sizes

Curated Selection

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