What is the catalog number for Anti-TYSY Antibody (C-term)?

The catalog number for Anti-TYSY Antibody (C-term) is A04320-3.

Is Anti-TYSY Antibody (C-term) in stock?

Anti-TYSY Antibody (C-term) is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-TYSY Antibody (C-term)?

The safety data sheet for Anti-TYSY Antibody (C-term) is available here: https://www.bosterbio.com/msds?sku=A04320-3.

Anti-TYSY Antibody (C-term)

Boster Bio Anti-TYSY Antibody (C-term) (Catalog # A04320-3) . Tested in Flow Cytometry, IF, IHC-P, WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

Synonyms

Thymidylate synthase, TS, TSase, TYMS, TS

Gene Name

TYMS

UniProt

P04818

Host

Rabbit

Reactivity

Human

Immunogen

This TYSY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human TYSY.

Clonality

Polyclonal

Applications

Flow Cytometry, IF, IHC-P, WB

Field of Research

Metabolism, Mitochondria

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Catalyzes the reductive methylation of 2'-deoxyuridine 5'- monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1- carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.