Anti-CP Antibody (N-term)
Boster Bio Anti-CP Antibody (N-term) (Catalog # A02883) . Tested in WB, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human, Mouse.
Product Specifications
Background
CP is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe (II) transferrin to Fe (III) transferrin. Mutations in this protein cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities.
Synonyms
Ceruloplasmin, Ferroxidase, CP
Gene Name
CP
UniProt
P00450
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This CP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-151 amino acids from the N-terminal region of human CP.
Clonality
Polyclonal
Tissue Specificity
Expressed by the liver and secreted in plasma.
Applications
WB, Flow Cytometry, IHC-P
Field of Research
Cardiovascular, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe (2+) to Fe (3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu (2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity) .
Molecular Weight
122205 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
Rabbit IgG
Subcellular Location
Secreted. Note=Colocalizes with GCP1 in secretory intracellular compartments.
Available Sizes
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