Anti-TLE1 Antibody (N-term)
Boster Bio Anti-TLE1 Antibody (N-term) (Catalog # A02460-1) . Tested in IF, WB application (s) . This antibody reacts with Human.
Product Specifications
Background
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Synonyms
Transducin-like enhancer protein 1, E (Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1, TLE1
Gene Name
TLE1
UniProt
Q04724
Host
Rabbit
Reactivity
Human
Immunogen
This TLE1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 187-221 amino acids from the N-terminal region of human TLE1.
Clonality
Polyclonal
Tissue Specificity
In all tissues examined, mostly in brain, liver and muscle
Applications
IF, WB
Field of Research
Signal Transduction, Stem Cells, Anti-Wnt-Pathway (plus Lgr5) Antibodies
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF- 1- and HES1-mediated transcriptional repression (By similarity) . The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Molecular Weight
83201 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
Rabbit IgG
Subcellular Location
Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components
Available Sizes
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