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Anti-CAD Antibody (Center)

Boster Bio Anti-CAD Antibody (Center) (Catalog # A00463-3) . Tested in WB, IHC-P, Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Background

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.

Synonyms

CAD protein, Glutamine-dependent carbamoyl-phosphate synthase, Aspartate carbamoyltransferase, Dihydroorotase, CAD

Gene Name

CAD

UniProt

P27708

Host

Rabbit

Reactivity

Human

Immunogen

This CAD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 780-809 amino acids from the Central region of human CAD.

Clonality

Polyclonal

Applications

WB, IHC-P, Flow Cytometry

Field of Research

Cell Biology, Metabolism

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) .

Molecular Weight

242984 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00463-3

Product MSDS

https://www.bosterbio.com/msds?sku=A00463-3

Fragment

Rabbit IgG

Subcellular Location

Cytoplasm. Nucleus. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth

Prediction Reactivity

Mouse

Available Sizes

Curated Selection

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