Anti-PCSK9 Antibody (N-term)
Boster Bio Anti-PCSK9 Antibody (N-term) (Catalog # A00085-3) . Tested in Flow Cytometry, IHC-P, WB application (s) . This antibody reacts with Human.
Product Specifications
Background
PCSK9 is a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. The protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
Synonyms
Proprotein convertase subtilisin/kexin type 9, 3421-, Neural apoptosis-regulated convertase 1, NARC-1, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9, PCSK9, NARC1
Gene Name
PCSK9
UniProt
Q8NBP7
Host
Rabbit
Reactivity
Human
Immunogen
This PCSK9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-183 amino acids from the N-terminal region of human PCSK9.
Clonality
Polyclonal
Tissue Specificity
Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells
Applications
Flow Cytometry, IHC-P, WB
Field of Research
Cardiovascular, Cell Biology, Metabolism, Signal Transduction, Lysosome
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
180396581879945817461796181977022207482718660751
Molecular Weight
74286 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
Rabbit IgG
Subcellular Location
Cytoplasm. Secreted. Endosome. Lysosome. Cell surface. Endoplasmic reticulum. Golgi apparatus. Note=Autocatalytic cleavage is required to transport it from the endoplasmic reticulum to the Golgi apparatus and for the secretion of the mature protein Localizes to the endoplasmic reticulum in the absence of LDLR and colocalizes to the cell surface and to the endosomes/lysosomes in the presence of LDLR. The sorting to the cell surface and endosomes is required in order to fully promote LDLR degradation
Available Sizes
Frequently Asked Questions
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