Anti-DKK2 Antibody
Boster Bio Anti-DKK2 Antibody (Catalog # M06431) . Tested in WB application (s) . This antibody reacts with Human, Mouse.
Product Specifications
Background
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) .
Synonyms
Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2, DKK2
Gene Name
DKK2
UniProt
Q9UBU2
Host
Mouse
Reactivity
Human, Mouse
Immunogen
This DKK2 antibody is generated from a mouse immunized with a recombinant protein of human DKK2.
Clonality
Monoclonal
Clone
Clone: 1833CT856.7.20
Tissue Specificity
Expressed in heart, brain, skeletal muscle and lung
Applications
WB
Field of Research
Stem Cells, Anti-Wnt-Pathway (plus Lgr5) Antibodies
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution
WB: 1:2000
Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) .
Molecular Weight
28447 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
IgG1, k
Subcellular Location
Secreted.
Available Sizes
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