Anti-PURB Antibody (C-term)
Boster Bio Anti-PURB Antibody (C-term) (Catalog # M06224) . Tested in WB application (s) . This antibody reacts with Human, Mouse.
Product Specifications
Background
Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity) .
Synonyms
Transcriptional activator protein Pur-beta, Purine-rich element-binding protein B, PURB
Gene Name
PURB
UniProt
Q96QR8
Host
Mouse
Reactivity
Human, Mouse
Immunogen
This PURB antibody is generated from a mouse immunized with a recombiant protein of human PURB.
Clonality
Monoclonal
Clone
Clone: 2117CT1176.48.6
Tissue Specificity
Expressed in myocardium of heart failure patients.
Applications
WB
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution
WB: 1:8000
Function
Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity) .
Molecular Weight
33241 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
IgG1, κ
Subcellular Location
Nucleus.
Prediction Reactivity
Human, Mouse
Available Sizes
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