Anti-HACE1 Antibody

Boster Bio Anti-HACE1 Antibody (Catalog # M04757) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

Synonyms

E3 ubiquitin-protein ligase HACE1, 6.3.2.-, HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1, HACE1, KIAA1320

Gene Name

HACE1

UniProt

Q8IYU2

Host

Mouse

Reactivity

Human

Immunogen

This HACE1 antibody is generated from a mouse immunized with a recombinant protein from the human region of human HACE1.

Clonality

Monoclonal

Clone

Clone: 1854CT757.66.47

Tissue Specificity

Expressed in multiple tissues including heart, brain and kidney.

Applications

Field of Research

Cancer, Cell Biology

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Dilution

WB: 1:2000

Function

Molecular Weight

102342 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M04757

Product MSDS

https://www.bosterbio.com/msds?sku=M04757

Fragment

IgG1, k

Subcellular Location

Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. Note=A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins

Available Sizes

Curated Selection

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