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Anti-FOLR2 Antibody

Boster Bio Anti-FOLR2 Antibody (Catalog # M04574-1) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

Synonyms

Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FOLR2

Gene Name

FOLR2

UniProt

P14207

Host

Mouse

Reactivity

Human

Immunogen

This FOLR2 antibody is generated from a mouse immunized with a recombiant protein from human FOLR2.

Clonality

Monoclonal

Clone

Clone: 1905CT501.41.76

Tissue Specificity

Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues

Applications

WB

Field of Research

Cardiovascular, Immunology, Metabolism, Signal Transduction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Dilution

WB: 1:1000-1:2000

Function

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

Molecular Weight

29280 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Fragment

IgG2b, κ

Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Secreted

Available Sizes

Frequently Asked Questions

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