Anti-FZR Antibody
Boster Bio Anti-FZR Antibody (Catalog # M03219) . Tested in WB application (s) . This antibody reacts with Human.
Product Specifications
Background
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Synonyms
Fizzy-related protein homolog, Fzr, CDC20-like protein 1, Cdh1/Hct1 homolog, hCDH1, FZR1, CDH1, FYR, FZR, KIAA1242
Gene Name
FZR1
UniProt
Q9UM11
Host
Mouse
Reactivity
Human
Immunogen
This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR.
Clonality
Monoclonal
Clone
Clone: 1621CT637.76.67
Tissue Specificity
Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues.
Applications
WB
Field of Research
Cell Biology
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution
WB: 1:2000
Function
25349192
Molecular Weight
55179 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
IgG1, k
Subcellular Location
[Isoform 2]: Nucleus
Available Sizes
Frequently Asked Questions
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