What is the catalog number for Anti-SMURF2 Antibody?

The catalog number for Anti-SMURF2 Antibody is M02585-1.

Is Anti-SMURF2 Antibody in stock?

Anti-SMURF2 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-SMURF2 Antibody?

The safety data sheet for Anti-SMURF2 Antibody is available here: https://www.bosterbio.com/msds?sku=M02585-1.

Anti-SMURF2 Antibody

Boster Bio Anti-SMURF2 Antibody (Catalog # M02585-1) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

Synonyms

E3 ubiquitin-protein ligase SMURF2, hSMURF2, 6.3.2.-, SMAD ubiquitination regulatory factor 2, SMAD-specific E3 ubiquitin-protein ligase 2, SMURF2

Gene Name

SMURF2

UniProt

Q9HAU4

Host

Mouse

Reactivity

Human

Immunogen

This SMURF2 antibody is generated from a mouse immunized with a recombinant protein of human SMURF2.

Clonality

Monoclonal

Clone

Clone: 1826CT865.51.28

Tissue Specificity

Widely expressed.

Applications

Field of Research

Stem Cells

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Dilution

WB: 1:2000-1:4000

Function

11016919111632101271744021791611184480691101691911158580113894441138944430696809

Molecular Weight

86196 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Fragment

IgG1, k

Subcellular Location

Nucleus. Cytoplasm. Cell membrane. Membrane raft. Note=Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts