Anti-SLC22A2 Antibody (N-term)

Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4- (dimethylamino) -styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.

This SLC22A2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 57-89 amino acids from the N-terminal region of human SLC22A2.

Mainly expressed in kidney, in the cortex and medulla (PubMed:9260930, PubMed:12089365, PubMed:11912245) . Localized in testis, mostly to peritubular myoid cells and Leydig cells and also detected along the basal membrane of Sertoli cells (PubMed:12089365, PubMed:35307651) . Expressed in brain, in neurons of the cerebral cortex and in various subcortical nuclei (PubMed:9260930, PubMed:12089365, PubMed:9687576) . In the brain, also detected in the dopaminergic regions of the substantia nigra (PubMed:17460754) . Expressed in tracheal and bronchial ciliated epithelium in the respiratory tract (PubMed:15817714) . Also detected in secretory phase endometrium, in scattered stromal cells (PubMed:17393420) . Expressed in spleen, placenta, small intestine and spinal cord (PubMed:9260930, PubMed:12089365) . Weakly expressed in prostate, uterus and lung (PubMed:12089365) .

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Basolateral cell membrane {ECO:0000250|UniProtKB:Q9R0W2}; Multi-pass membrane protein. Basal cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Localized to the basal membrane of Sertoli cells (PubMed:35307651) . Localized to the basolateral membrane of proximal tubule (PubMed:11912245) . Localized to the luminal/apical membrane of distal tubule (PubMed:9260930) . Localized to the luminal/apical membrane of ciliated epithelial cells in bronchi (PubMed:15817714) .