What is the catalog number for Anti-SLC22A2 Antibody (N-term)?

The catalog number for Anti-SLC22A2 Antibody (N-term) is M01612.

Is Anti-SLC22A2 Antibody (N-term) in stock?

Anti-SLC22A2 Antibody (N-term) is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-SLC22A2 Antibody (N-term)?

The safety data sheet for Anti-SLC22A2 Antibody (N-term) is available here: https://www.bosterbio.com/msds?sku=M01612.

Anti-SLC22A2 Antibody (N-term)

Boster Bio Anti-SLC22A2 Antibody (N-term) (Catalog # M01612) . Tested in WB, IHC-P, Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Background

Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4- (dimethylamino) -styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity.

Synonyms

Solute carrier family 22 member 2, Organic cation transporter 2, hOCT2, SLC22A2, OCT2

Gene Name

SLC22A2

UniProt

O15244

Host

Rabbit

Reactivity

Human

Immunogen

This SLC22A2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 57-89 amino acids from the N-terminal region of human SLC22A2.

Clonality

Polyclonal

Tissue Specificity

Mainly expressed in kidney, in the cortex and medulla (PubMed:9260930, PubMed:12089365, PubMed:11912245) . Localized in testis, mostly to peritubular myoid cells and Leydig cells and also detected along the basal membrane of Sertoli cells (PubMed:12089365, PubMed:35307651) . Expressed in brain, in neurons of the cerebral cortex and in various subcortical nuclei (PubMed:9260930, PubMed:12089365, PubMed:9687576) . In the brain, also detected in the dopaminergic regions of the substantia nigra (PubMed:17460754) . Expressed in tracheal and bronchial ciliated epithelium in the respiratory tract (PubMed:15817714) . Also detected in secretory phase endometrium, in scattered stromal cells (PubMed:17393420) . Expressed in spleen, placenta, small intestine and spinal cord (PubMed:9260930, PubMed:12089365) . Weakly expressed in prostate, uterus and lung (PubMed:12089365) .

Applications

WB, IHC-P, Flow Cytometry

Field of Research

Signal Transduction

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

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Molecular Weight

62581 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Fragment

Rabbit IgG

Subcellular Location

Basolateral cell membrane {ECO:0000250|UniProtKB:Q9R0W2}; Multi-pass membrane protein. Basal cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Localized to the basal membrane of Sertoli cells (PubMed:35307651) . Localized to the basolateral membrane of proximal tubule (PubMed:11912245) . Localized to the luminal/apical membrane of distal tubule (PubMed:9260930) . Localized to the luminal/apical membrane of ciliated epithelial cells in bronchi (PubMed:15817714) .