What is the catalog number for Anti-RAB11A Antibody?

The catalog number for Anti-RAB11A Antibody is M01436-1.

Is Anti-RAB11A Antibody in stock?

Anti-RAB11A Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-RAB11A Antibody?

The safety data sheet for Anti-RAB11A Antibody is available here: https://www.bosterbio.com/msds?sku=M01436-1.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

Is this product suitable for live cell imaging?

Suitability for live cell imaging depends on the specific reagent and conjugate used. Check the datasheet for imaging-specific validation, or contact us for guidance.

Anti-RAB11A Antibody

Boster Bio Anti-RAB11A Antibody (Catalog # M01436-1) . Tested in WB, IHC-P application (s) . This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.

Synonyms

Ras-related protein Rab-11A, Rab-11, YL8, RAB11A, RAB11

Gene Name

RAB11A

UniProt

P62491

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

This RAB11A antibody is generated from a mouse immunized with a purified recombinant protein of human RAB11A.

Clonality

Monoclonal

Clone

Clone: 1565CT164.36.80

Applications

WB, IHC-P

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

20026645200266451560189625673879312041733120417332344433

Molecular Weight

24394 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Fragment

IgG1, κ

Subcellular Location

Cell membrane; Lipid-anchor. Endosome membrane. Recycling endosome membrane; Lipid-anchor. Cleavage furrow. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle membrane. Golgi apparatus. Golgi apparatus, trans-Golgi network. Note=Localized to WDR44-positive endosomes and tubules (PubMed:32344433) . Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279) . During interphase, localized in vesicles continuously moving from peripheral sorting endosomes towards the pericentrosomal ERC (PubMed:20026645) . Localizes to the cleavage furrow (PubMed:15601896) . Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297) Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211) . Localized to rhodopsin transport carriers when interacting with RAB11AFIP3 and ASAP1 in photoreceptors (PubMed:25673879) .