Anti-STUB1 Antibody (C-term)
Boster Bio Anti-STUB1 Antibody (C-term) (Catalog # M01236-1) . Tested in WB application (s) . This antibody reacts with Human, Mouse.
Product Specifications
Background
E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF- BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation.
Synonyms
HGNC:11427
Gene Name
STUB1
UniProt
Q9UNE7
Host
Mouse
Reactivity
Human, Mouse
Immunogen
This STUB1 antibody is generated from a mouse immunized with a recombinant protein of human STUB1.
Clonality
Monoclonal
Clone
Clone: 1008CT12.4.1
Tissue Specificity
Expressed in differentiated myotubes (at protein level) (PubMed:17369820) . Highly expressed in skeletal muscle, heart, pancreas, brain and placenta (PubMed:10330192, PubMed:11435423) Detected in kidney, liver and lung (PubMed:10330192, PubMed:11435423)
Applications
WB
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution
WB: 1:4000
Function
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Molecular Weight
34856 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
IgG1, k
Subcellular Location
Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to inflammatory signals in regulatory T-cells (Treg)
Available Sizes
Frequently Asked Questions
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