Anti-NR3C1

Boster Bio Anti-NR3C1 (Catalog # M00503-2) . Tested in WB application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

27120390959069625775514

Synonyms

Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL

Gene Name

NR3C1

UniProt

P04150

Host

Mouse

Reactivity

Human, Mouse

Immunogen

This antibody is generated from a mouse immunized with a recombinant protein from human.

Clonality

Monoclonal

Clone

Clone: 2153CT307.32.80

Tissue Specificity

Widely expressed including bone, stomach, lung, liver, colon, breast, ovary, pancreas and kidney (PubMed:25847991) . In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart (PubMed:10902803) [Isoform Alpha-2]: Widely expressed.

Applications

Field of Research

Cancer, Signal Transduction, Mitochondria

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Dilution

WB: 1:2000

Function

2712039028139699959069625775514

Molecular Weight

85659 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Fragment

IgG1, κ

Subcellular Location

[Isoform Alpha]: Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=After ligand activation, translocates from the cytoplasm to the nucleus. In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20 (By similarity) . Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20 (By similarity) . {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:18838540, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:8621628} [Isoform Alpha-B]: Nucleus. Cytoplasm Note=After ligand activation, translocates from the cytoplasm to the nucleus.