Anti-PINK1 Antibody
Boster Bio Anti-PINK1 Antibody (Catalog # M00201) . Tested in WB, IHC-P, IF application (s) . This antibody reacts with Human.
Product Specifications
Background
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.
Synonyms
Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, PTEN-induced putative kinase protein 1, PINK1
Gene Name
PINK1
UniProt
Q9BXM7
Host
Mouse
Reactivity
Human
Immunogen
Recombinant PINK1 protein was used to produced this monoclonal antibody.
Clonality
Monoclonal
Clone
Clone: 38CT20.8.5
Tissue Specificity
Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development
Applications
WB, IHC-P, IF
Field of Research
Cardiovascular, Metabolism, Neuroscience, Signal Transduction, Autophagy, Mitochondria
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Function
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Molecular Weight
62769 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
IgG1
Subcellular Location
Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q99MQ3}; Single-pass membrane protein. Cytoplasm, cytosol. Note=Localizes mostly in mitochondrion and the two smaller proteolytic processed fragments localize mainly in cytosol (PubMed:19229105) . When mitochondria lose mitochondrial membrane potential following damage, PINK1 import is arrested, which induces its accumulation in the outer mitochondrial membrane, where it acquires kinase activity (PubMed:18957282)
Available Sizes
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