What is the catalog number for Anti-CDK4 Antibody?

The catalog number for Anti-CDK4 Antibody is M00159-2.

Is Anti-CDK4 Antibody in stock?

Anti-CDK4 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-CDK4 Antibody?

The safety data sheet for Anti-CDK4 Antibody is available here: https://www.bosterbio.com/msds?sku=M00159-2.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Anti-CDK4 Antibody

Boster Bio Anti-CDK4 Antibody (Catalog # M00159-2) . Tested in WB, IHC-P application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G (1) /S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Synonyms

Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3, CDK4

Gene Name

CDK4

UniProt

P11802

Host

Mouse

Reactivity

Human, Mouse

Immunogen

This CDK4 antibody is generated from a mouse immunized with a recombinant protein.

Clonality

Monoclonal

Clone

Clone: 1529CT850.162.73

Applications

WB, IHC-P

Field of Research

Cancer, Cell Biology, T Cells

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Molecular Weight

33730 Da

Shipping Conditions

Available

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Fragment

IgG2a, κ

Subcellular Location

Cytoplasm. Nucleus. Nucleus membrane. Note=Cytoplasmic when non-complexed Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G (1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G (1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.