Anti-Human CD11a ITGAL Monoclonal Antibody FITC Conjugated, Flow Validated

Boster Bio Anti-Human CD11a ITGAL Monoclonal Antibody FITC Conjugated, Flow Validated (Catalog# FC04466-FITC) . Tested in Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Synonyms

Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11a; ITGAL; CD11A

Gene Name

ITGAL

UniProt

P20701

Host

Mouse

Reactivity

Human

Immunogen

Human HLA-DRCTL line cytolytic Tlymphocytes

Clonality

Monoclonal

Clone

Clone: Clone: TS1/22

Conjugation

FITC

Tissue Specificity

Leukocytes.

Applications

Flow Cytometry

Field of Research

Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Myeloid, Signal Transduction, Stem Cells

Purification

Affinity column chromatography

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

User needs to optimize the dilution ratio for this antibody.

Form

Liquid, in PBS, pH7.2, <0.09% NaN3 and 0.2% (w/v) BSA

Function

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364) . Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110) . Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992) . Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity) . Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590) . .