Anti-human CD8 Cd8a Monoclonal Antibody PE Conjugated, Flow Validated

Boster Bio Anti-human CD8 Cd8a Monoclonal Antibody PE Conjugated, Flow Validated (Catalog# FC02236-PE) . Tested in Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Background

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. It is mapped to 2p11.2. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene also encodes the CD8 alpha chain isoforms.

Synonyms

T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein Lyt-2; CD8a; Cd8a; Lyt-2, Lyt2

Gene Name

Cd8a

UniProt

P01732

Host

Mouse

Reactivity

Human

Immunogen

Human peripheral blood T lymphocytes

Clonality

Monoclonal

Clone

Clone: Clone: OKT8

Conjugation

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, Immunology, T Cells

Purification

Protein A purified

Sensitivity

5ul per sample

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

User needs to optimize the dilution ratio for this antibody.

Form

Liquid

Function

Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.