Anti-Human CD45 PTPRC Monoclonal Antibody iFluor488 Conjugated, Flow Validated

Boster Bio Anti-Human CD45 PTPRC Monoclonal Antibody iFluor488 Conjugated, Flow Validated (Catalog# FC00555-iFluor488) . Tested in Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Synonyms

Receptor-type tyrosine-protein phosphatase C;3.1.3.48; Leukocyte common antigen; L-CA; T200; CD45; PTPRC; CD45

Gene Name

PTPRC

UniProt

P08575

Host

Mouse

Reactivity

Human

Immunogen

Human T lymphocytes

Clonality

Monoclonal

Clone

Clone: Clone: F10-89-4

Conjugation

IFluor488

Applications

Flow Cytometry

Field of Research

Adapters, Adaptive Immunity, B Cells, Cell Type Markers, Immunology, Protein Phosphorylation, Signal Transduction, T Cells, Transmembrane, Tyrosine Phosphatases

Purification

Affinity column chromatography

Concentration

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Dilution

User needs to optimize the dilution ratio for this antibody.

Form

Liquid, in PBS, pH7.2, <0.09% NaN3 and 0.2% (w/v) BSA

Function

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity) . .