MANF Mesencephalic Astrocyte-Derived Neurotrophic Factor Mouse Recombinant Protein
MANF Mouse Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 158 amino acids and having a molecular mass of 18.2kDa.
Product Specifications
Synonyms
Mesencephalic astrocyte-derived neurotrophic factor; Arginine-rich protein; Protein ARMET; Manf; Armet
Gene Name
MANF
UniProt
Q9CXI5
Reactivity
Mouse
Tissue Specificity
Strongly expressed in pancreatic islets and spermatocytes (at protein level) .
Source
Escherichia coli
Sequence
[object Object]
Purification
Greater than 98.0% as determined by (a) Analysis by RP-HPLC and (b) Analysis by SDS-PAGE.
Bioactivity
50
Form
Sterile Filtered White lyophilized (freeze-dried) powder.
Reconstitution
It is recommended to reconstitute the lyophilized MANF in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Function
Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (By similarity) .
Shipping Conditions
Available
Storage Conditions
Lyophilized MANF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MANF should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.
Other Gene Names
Mesencephalic astrocyte-derived neurotrophic factor
Subcellular Location
Secreted
Available Sizes
Frequently Asked Questions
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