Human, DnaK Human Recombinant Protein, His Tag

Heat shock 70 kDa protein; heat shock 70kDa protein 1A; HSP70.1; HSP70-1/HSP70-2; HSPA1A; HSPA1; HSPA1B; HSP72; HSP70I; HSP70-1; FLJ54303; FLJ54370; FLJ54392; FLJ54408; FLJ75127; HSP70-1A

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223) .

Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Avoid multiple freeze-thaw cycles.