XRCC2 X-Ray Repair Cross Complementing Protein 2 Human Recombinant Protein
XRCC2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 303 amino acids (1-280) and having a molecular mass of 34.3 kDa. XRCC2 is fused to a 23 amino acid His-tag at N-terminus.
Product Specifications
Synonyms
X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 2; X-Ray Repair Cross-Complementing Protein 2; RAD51-like; DNA Repair Protein XRCC2
Gene Name
XRCC2
UniProt
O43543
Reactivity
Human
Source
Escherichia coli
Sequence
[object Object]
Purification
Greater than 80% as determined by SDS-PAGE.
Form
Sterile Filtered clear solution.
Function
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Shipping Conditions
Available
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Avoid multiple freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=PROTO43543
Product MSDS
https://www.bosterbio.com/msds?sku=PROTO43543
Other Gene Names
DNA repair protein XRCC2
Subcellular Location
Nucleus
Available Sizes
Curated Selection
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