NFE2L2 Nuclear Factor Erythroid 2-Like 2 Human Recombinant Protein
NFE2L2 Human Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 625 amino acids (1-605 a.a) and having a molecular mass of 69.9kDa. NFE2L2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specifications
Synonyms
NFE2L2; Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor; erythroid derived 2; like 2; NRF2
Gene Name
NFE2L2
UniProt
Q16236
Reactivity
Human
Tissue Specificity
Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.
Source
Escherichia coli
Sequence
[object Object]
Purification
Greater than 85.0% as determined by SDS-PAGE.
Form
Sterile Filtered clear solution.
Function
Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.
Shipping Conditions
Available
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Avoid multiple freeze-thaw cycles.
Other Gene Names
Nuclear factor erythroid 2-related factor 2
Subcellular Location
Cytoplasm, cytosol. Nucleus. Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.
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