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ILK1 Integrin Linked Kinase Human Recombinant Protein

ILK1 Human Recombinant produced in E. coli is single, a non-glycosylated, Polypeptide chain containing 452 amino acids fragment (1-452) having a molecular mass of 55.92kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The ILK1 is purified by proprietary chromatographic techniques.

Product Specifications

Synonyms

Integrin-linked protein kinase; ILK-1; ILK-2; 59 kDa serine/threonine-protein kinase; p59ILK; ILK; ILK1; ILK2; DKFZp686F1765; P59

Gene Name

ILK

UniProt

Q13418

Reactivity

Human

Tissue Specificity

Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.

Source

Escherichia coli

Purification

Greater than 95.0% as determined by SDS-PAGE.

Form

Sterile Filtered clear solution.

Function

Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Shipping Conditions

Available

Storage Conditions

Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

Other Gene Names

Integrin-linked protein kinase

Subcellular Location

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium

Available Sizes

Frequently Asked Questions

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