REG3A Regenerating Islet-Derived 3 Alpha Human Recombinant Protein
The Recombinant Human REG3A protein is produced with N-terminal fusion of His Tag. The REG3A His -Tagged Fusion Protein is an 18.4 kDa protein containing 149 amino acid residues of the Human REG3A and 16 additional amino acid residues- His Tag (underlined) . Applications: ELISA, Western blot.
Product Specifications
Synonyms
Regenerating islet-derived protein 3 alpha; Reg III-alpha; Pancreatitis-associated protein 1; REG3A; HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; REG-III
Gene Name
REG3A
UniProt
Q06141
Reactivity
Human
Tissue Specificity
Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level) . Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.
Source
Escherichia coli
Sequence
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Applications
ELISA, WB
Purification
Greater than 95.0% as determined by SDS-PAGE.
Form
Filtered White lyophilized (freeze-dried) powder.
Reconstitution
Add 0.1M acetate buffer pH4 to prepare ~0.5mg/ml working stock solution. For higher pH, dilute with relevant buffer to 10μg/ml. The antigen has limited solubility in higher concentrations. Non-sterile product; filter before use in cell culture.
Function
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
Shipping Conditions
Available
Storage Conditions
Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Other Gene Names
Regenerating islet-derived protein 3-alpha
Subcellular Location
Secreted. Found in the apical region of pancreatic acinar cells.
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