PGRN Progranulin Human Recombinant Protein
Progranulin Human Recombinant produced in HEK is a single, glycosylated, polypeptide chain containing 1-593 amino acids and having a molecular mass of 74kDa. The Progranulin is purified by standard chromatographic techniques.
Product Specifications
Synonyms
GRN; PGRN; granulin; Acrogranin; propithelin; PC cell derived growth Factor; GEP; GP88; PEPI; PCDGF
Gene Name
GRN
UniProt
P28799
Reactivity
Human
Tissue Specificity
In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
Source
HEK293
Purification
Greater than 98.0% as determined by SDS-PAGE.
Bioactivity
Activates phospho-ERK1/2 in neuronal mouse P19 cells and regulates food intake and body weight.
Form
Sterile Filtered White lyophilized (freeze-dried) powder.
Reconstitution
2
Function
Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
Shipping Conditions
Available
Storage Conditions
Lyophilized Progranulin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PGRN should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.
Other Gene Names
Granulins
Subcellular Location
Secreted.
Available Sizes
Frequently Asked Questions
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