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PON1 Paraoxonase-1 Human Recombinant Protein

Paraoxonase-1 Isoform Human Recombinant is expressed in E. coli, fused to a 4.5kDa amino terminal hexahistidine tag, having a total molecular weight of 42.9kDa. The PON1 purified by proprietary chromatographic techniques.

Product Specifications

Synonyms

Serum paraoxonase; arylesterase 1; EC 3.1.1.2; EC 3.1.8.1; PON 1; Serum aryldialkylphosphatase 1; A-esterase 1; Aromatic esterase 1; K-45; ESA; PON

Gene Name

PON1

UniProt

P27169

Reactivity

Human

Tissue Specificity

Plasma, associated with HDL (at protein level) . Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.

Source

Escherichia coli

Sequence

[object Object]

Purification

Greater than 95% as determined by SDS-PAGE. Single band on Western Blot.

Form

Sterile Filtered clear solution.

Function

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.

Shipping Conditions

Available

Storage Conditions

Store at 4°C if entire vial will be used within 1-2 weeks. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

Other Gene Names

Serum paraoxonase/arylesterase 1

Subcellular Location

Secreted, extracellular space.

Available Sizes

Frequently Asked Questions

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