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LBP Lipopolysaccaride Human Recombinant Protein

The Lipopolysaccharide Binding Protein is produced from human LBP transfected CHO-cells in serum free medium. Before transfection the complete human LBP-cDNA was amplified by PCR and cloned into expression vector p-POL-DHFR. The recombinant Human LBP was purified by his-tag with metal affinity purification with Talon and controlled by SDS page. Showing a 58kDa band on SDS-PAGE. Attention: His-tag has no protease site and can not be split off.

Product Specifications

Synonyms

Lipopolysaccharide-binding protein; LBP; MGC22233

Gene Name

LBP

UniProt

P18428

Reactivity

Human

Tissue Specificity

Detected in blood serum (at protein level) .

Source

CHO cells

Bioactivity

Up to 0.2 μg/ ml LBP mediates binding of FITC-LPS (0.5μg/ml) to CD14+CHO transfectants (FACS) .

Form

Sterile Filtered White lyophilized (freeze-dried) powder.

Reconstitution

2

Function

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359) . Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359) .

Shipping Conditions

Available

Storage Conditions

Lyophilized LBP Human Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution LBP should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=PROTP18428

Product MSDS

https://www.bosterbio.com/msds?sku=PROTP18428

Other Gene Names

Lipopolysaccharide-binding protein

Subcellular Location

Secreted

Available Sizes

Curated Selection

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