BPI Bactericidal/Permeability-Increasing Protein Human
The native protein BPI is isolated from human buffy coats and has a molecular mass of 53kDa.
Product Specifications
Synonyms
Bactericidal/permeability-increasing protein; CAP 57
Gene Name
BPI
UniProt
P17213
Reactivity
Human
Tissue Specificity
Restricted to cells of the myeloid series.
Purification
Greater than 70% as determined by SDS-PAGE and capillary electrophoresis.
Function
The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Shipping Conditions
Available
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Other Gene Names
Bactericidal permeability-increasing protein
Subcellular Location
Secreted
Available Sizes
Frequently Asked Questions
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