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P-selectin Human Recombinant Protein

Selected Variant

PROTP16109-01

Size: 2 µg

P-Selectin Human Recombinant is expressed in E. coli containing 566 amino acids 197-761 fused to an amino terminal hexahistidine tag. Applications: P-Selectin can be used directly as a positive control in Western blotting, ELISA, immunoprecipitation and other immunological experiments.

Product Specifications

Synonyms

P-selectin; Granule membrane protein 140; GMP-140; PADGEM; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; CD62 antigen-like family member P; CD62P antigen; SELP; GMRP; GRMP; CD62; PSEL; CD62P; GMP140; FLJ45155

Gene Name

SELP

UniProt

P16109

Reactivity

Human

Tissue Specificity

Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Source

Escherichia coli

Applications

WB, ELISA, IP

Purification

Greater than 95% as determined by SDS-PAGE. Single band on Western Blot.

Bioactivity

The biological activity of this product has not yet been tested.

Form

Sterile Filtered liquid formulation.

Function

Ca (2+) -dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.

Shipping Conditions

Available

Storage Conditions

Store at 4°C if entire vial will be used within 1-2 weeks. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

Other Gene Names

P-selectin

Subcellular Location

Membrane; Single-pass type I membrane protein.

Available Sizes

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