(-) -Pinoresinol 4-O-glucoside

(-) -Pinoresinol 4-O-glucoside ((-) -Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC50 value of 48.13 µM. (-) -Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-) -Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-) -Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-) -Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease[1][2].

Product Specifications

CAS Number

[41607-20-9]

Product Name Alternative

(-) -Pinoresinol 4-O-β-D-glucopyranoside

UNSPSC

12352005

Target

Glycosidase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/minus-pinoresinol-4-o-glucoside.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C([C@@H]3OC[C@]4([H])[C@@]3([H])CO[C@H]4C5=CC=C(O)C(OC)=C5)C=C2OC

Molecular Formula

C26H32O11

Molecular Weight

520.53

References & Citations

[1]Park KR, et al. Effects of PIN on Osteoblast Differentiation and Matrix Mineralization through Runt-Related Transcription Factor. Int J Mol Sci. 2020 Dec 16;21 (24) :9579.|[2]Youssef FS, et al. Pinoresinol-4-O-β-D-glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo. J Pharm Pharmacol. 2020 Dec;72 (12) :1830-1839.