Human KLK11/Kallikrein-11 ELISA Kit PicoKine®, Carrier-free

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.

<table cellpadding="3"><tr><th>Lots</th><th>Lot 1 (pg/ml)</th><th>Lot 2 (pg/ml)</th><th>Lot 3 (pg/ml)</th><th>Lot 4 (pg/ml)</th><th>Mean (pg/ml)</th><th>Standard Deviation</th><th>CV (%)</th></tr><tr><td>Sample 1</td><td>217</td><td>206</td><td>233</td><td>215</td><td>217</td><td>9.73</td><td>4.4%</td></tr><tr><td>Sample 2</td><td>1054</td><td>1031</td><td>1100</td><td>1045</td><td>1057</td><td>25.86</td><td>2.4%</td></tr><tr><td>Sample 3</td><td>4898</td><td>4850</td><td>4518</td><td>5291</td><td>4889</td><td>274.24</td><td>5.6%</td></tr></table>*number of samples for each test n=16.

Kallikrein-11;hK11;3.4.21.-;Hippostasin;Serine protease 20;Trypsin-like protease;Kallikrein-11 inactive chain 1;Kallikrein-11 inactive chain 2;KLK11;PRSS20, TLSP;UNQ649/PRO1279;

Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level). .

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. .

Description|Quantity Pre-coated 96-well strip microplate|1 Standard|2 vials Biotinylated antibody (100x)|100ul Avidin-Biotin-Peroxidase Complex (100x)|100ul Sample Diluent|30ml Antibody Diluent|12ml Avidin-Biotin-Peroxidase Diluent|12ml Color Developing Reagent (TMB)|10ml Stop Solution|10ml Wash Buffer (25x)|20ml Adhesive plate sealers|4

Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)