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Mouse IL-23R ELISA Kit EZ-Set™ (DIY Antibody Pairs), Carrier-free

Selected Variant

EZ1613-carrier-free

Size: 5 Plates/Kit

Mouse IL-23R ELISA Kit EZ-Set™ (DIY Antibody Pairs) (antibody pairs and standards for assay development). Quantitate Mouse Il23r in cell culture supernatants, serum and plasma (heparin, EDTA).

Product Specifications

Background

Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene. The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

Synonyms

Interleukin-23 receptor; IL-23 receptor; IL-23R; Il23r

Gene Name

interleukin 23 receptor

Gene ID

209590

UniProt

Q8K4B4

Reactivity

Mouse

Cross Reactivity

There is no detectable cross-reactivity with other relevant proteins.

Immunogen

Expression system for standard: NS0; Immunogen sequence: I25-I373

Tissue Specificity

Expressed by Th1, Th2 and dendritic cells.

Applications

ELISA

Sample Type

cell culture supernatants, serum and plasma (heparin, EDTA).

Detection Range

78 pg/ml - 5,000 pg/ml

Function

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis (By similarity). .

Components

Description Capture Antibody Detection Antibody Avidin-Biotin-Peroxidase Complex (ABC) Lyophilized Standard|

Storage Conditions

Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Specificity

Natural and recombinant mouse IL-23R

Anticoagulant

heparin or EDTA

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

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