Anti-PTPN2 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-PTPN2 Rabbit Monoclonal Antibody catalog # M01597. Tested in WB, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

E3 ubiquitin-protein ligase NEDD4-like;6.3.2.-;NEDD4.2;Nedd4-2;NEDD4L;KIAA0439, NEDL3;

Gene Name

E3 ubiquitin-protein ligase NEDD4-like

UniProt

P18031/P17706

Host

Rabbit

Reactivity

Human,Mouse

Immunogen

A synthesized peptide derived from human PTPN2

Clonality

Monoclonal

Clone

Clone: 27P66

Tissue Specificity

Ubiquitously expressed, with highest levels in prostate, pancreas and kidney (PubMed:14615060, PubMed:15496141, PubMed:19664597). Expressed in melanocytes (PubMed:23999003). .

Applications

WB,IP,Flow Cytometry

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then ly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). .

Components

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Storage Conditions

Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

111932 MW

Observed Molecular Weight

40-48 kDa

Fragment

IgG

Applications Notes

WB 1:500-1:2000<br>IP 1:50<br>FC 1:50

Subcellular Location

Cytoplasm . May be recruited to exosomes by NDFIP1.

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

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