Anti-CTNNBIP1 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-CTNNBIP1 Rabbit Monoclonal Antibody catalog # M03185. Tested in WB, IP, Flow Cytometry applications. This antibody reacts with Human.

Product Specifications

Synonyms

rRNA 2'-O-methyltransferase fibrillarin;2.1.1.-;34 kDa nucleolar scleroderma antigen;Histone-glutamine methyltransferase;FBL;FIB1, FLRN;

Gene Name

rRNA 2'-O-methyltransferase fibrillarin

UniProt

Q9NSA3

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human CTNNBIP1

Clonality

Monoclonal

Clone

Clone: 27C17

Tissue Specificity

In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain. .

Applications

WB,IP,Flow Cytometry

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239). .