Anti-Human IgG1 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-Human IgG1 Rabbit Monoclonal Antibody catalog # M04575-6. Tested in WB application. This antibody reacts with Human.

Product Specifications

Synonyms

Ig gamma-1 chain C region;IGHG1;

Gene Name

Ig gamma-1 chain C region

UniProt

P01857

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human IgG1

Clonality

Monoclonal

Clone

Clone: 27I03

Tissue Specificity

According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor- derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.

Applications

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. .