Anti-SBDS Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-SBDS Rabbit Monoclonal Antibody catalog # M02396. Tested in WB application. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

NAD-dependent protein deacylase sirtuin-5, mitochondrial ;3.5.1.- ;Regulatory protein SIR2 homolog 5 ;SIR2-like protein 5 ;SIRT5 ;SIR2L5;

Gene Name

NAD-dependent protein deacylase sirtuin-5, mitochondrial

UniProt

Q9Y3A5

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

A synthesized peptide derived from human SBDS

Clonality

Monoclonal

Clone

Clone: 26S97

Tissue Specificity

Widely expressed. .

Applications

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. .

Components

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Storage Conditions

Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

33881 MW

Observed Molecular Weight

29 kDa

Fragment

IgG

Applications Notes

WB 1:500-1:2000

Subcellular Location

Mitochondrion matrix. Mitochondrion intermembrane space. Cytoplasm, cytosol. Nucleus. Mainly mitochondrial. Also present extramitochondrially: a fraction is present in the cytosol and very small amounts are also detected in the nucleus.