Anti-TRAP1 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-TRAP1 Rabbit Monoclonal Antibody catalog # M02426-4. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

Product Specifications

Synonyms

Heat shock protein 75 kDa, mitochondrial;HSP 75;TNFR-associated protein 1;Tumor necrosis factor type 1 receptor-associated protein;TRAP-1;TRAP1;HSP75;

Gene Name

Heat shock protein 75 kDa, mitochondrial

UniProt

Q12931

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human TRAP1

Clonality

Monoclonal

Clone

Clone: 23T98

Tissue Specificity

Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors. .

Applications

WB,IHC,ICC,IF

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. .