Anti-TIMM50 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-TIMM50 Rabbit Monoclonal Antibody catalog # M10056-1. Tested in WB, IHC applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Cysteine protease ATG4C;3.4.22.-;AUT-like 3 cysteine endopeptidase;Autophagin-3;Autophagy-related cysteine endopeptidase 3;Autophagy-related protein 4 homolog C;ATG4C;APG4C, AUTL1, AUTL3;

Gene Name

Cysteine protease ATG4C

UniProt

Q3ZCQ8

Host

Rabbit

Reactivity

Human,Mouse

Immunogen

A synthesized peptide derived from human TIMM50

Clonality

Monoclonal

Clone

Clone: 22T54

Tissue Specificity

Highly expressed in skeletal muscle, heart, liver and testis. .

Applications

WB,IHC

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. .