Anti-Desmoplakin Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-Desmoplakin Rabbit Monoclonal Antibody catalog # M00616. Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Rat.

Product Specifications

Synonyms

Tyrosine-protein phosphatase non-receptor type 1;3.1.3.48;Protein-tyrosine phosphatase 1B;PTP-1B;PTPN1;PTP1B;

Gene Name

Tyrosine-protein phosphatase non-receptor type 1

UniProt

P15924

Host

Rabbit

Reactivity

Human,Rat

Immunogen

A synthesized peptide derived from human Desmoplakin

Clonality

Monoclonal

Clone

Clone: 22D49

Tissue Specificity

Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum. .

Applications

WB,ICC,IF,Flow Cytometry

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. .