Anti-RING1 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-RING1 Rabbit Monoclonal Antibody catalog # M01824-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

Product Specifications

Synonyms

Midkine;MK;Amphiregulin-associated protein;ARAP;Midgestation and kidney protein;Neurite outgrowth-promoting factor 2;Neurite outgrowth-promoting protein;MDK;MK1, NEGF2;

Gene Name

Midkine

UniProt

Q06587

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human RING1

Clonality

Monoclonal

Clone

Clone: 22R33

Tissue Specificity

Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions. .

Applications

WB,IHC,ICC,IF

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). .