Anti-Mad2L1 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-Mad2L1 Rabbit Monoclonal Antibody catalog # M00785-2. Tested in WB application. This antibody reacts with Human.

Product Specifications

Synonyms

Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA;1.14.11.-;60S ribosomal protein L27a histidine hydroxylase;Histone lysine demethylase MINA;MYC-induced nuclear antigen;Mineral dust-induced gene protein;Nucleolar protein 52;Ribosomal oxygenase MINA;ROX;MINA ;MDIG , MINA53 , NO52 ;

Gene Name

Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA

UniProt

Q13257

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Mad2L1

Clonality

Monoclonal

Clone

Clone: 20M74

Tissue Specificity

Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines. .

Applications

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. .