Anti-FHL2 Rabbit Monoclonal Antibody, Carrier-free

Boster Bio Anti-FHL2 Rabbit Monoclonal Antibody catalog # M02129-1. Tested in WB, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Disks large homolog 4;Postsynaptic density protein 95;PSD-95;Synapse-associated protein 90;SAP-90;SAP90;DLG4;PSD95;

Gene Name

Disks large homolog 4

UniProt

Q14192

Host

Rabbit

Reactivity

Human,Mouse,Rat

Immunogen

A synthesized peptide derived from human FHL2

Clonality

Monoclonal

Clone

Clone: 19F25

Tissue Specificity

Brain.

Applications

WB,ICC,IF,IP

Purification

Affinity-chromatography

Concentration

Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Form

Liquid

Reconstitution

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Function

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). .

Components

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Storage Conditions

Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

80495 MW

Observed Molecular Weight

32 kDa

Fragment

IgG

Applications Notes

WB 1:500-1:1000<br>ICC/IF 1:50-1:200<br>IP 1:40

Subcellular Location

Cell membrane ; Peripheral membrane protein . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell projection, axon . Cell junction, synapse . High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells.